Search results for "early-stage breast cancer"

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Adjuvant denosumab in early breast-cancer

2020

We read with interest the D-CARE trial report by Robert Coleman and colleagues1 on the adjuvant administration of denosumab in patients with early-stage breast cancer. Despite the negative results, which pose concerns about high dose denosumab schedules in an adjuvant setting, this large and well- designed trial can provide useful clinical data that are usually difficult to obtain from observational studies, particularly regarding medication- related osteonecrosis of the jaw (MRONJ).

Oncologymedicine.medical_specialtyadjuvant denosumab early-stage breast cancerBone Density Conservation AgentsAromatase Inhibitorsbusiness.industrymedicine.medical_treatmentMEDLINEantiresorptives denosumab breast cancer osteonecrosis od the jawosteonecrosis od the jawdenosumabantiresorptivesBone Density Conservation Agentsbreast cancerDenosumabOncologyInternal medicineMedicinebusinessAdjuvantmedicine.drugEarly breast cancerThe Lancet Oncology
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Analysis of cardiac and pulmonary complication probabilities after radiation therapy for patients with early-stage breast cancer

2009

Objective. The purpose of this study was to evaluate the radiobiological implications of clinical use of respiratory-gated techniques for postoperative radiation therapy of early-stage left-sided breast cancer after breast-conserving surgery. Material and methods. Radiation therapy treatment plans of 80 patients with early-stage breast cancer (stage I–II), receiving whole breast irradiation after breast-conserving therapy, were analyzed. The control group consisting of 47 patients received standard radiation therapy, and the respiratory-gated group consisting of 33 patients received deep inspiration-gated radiation therapy. Normal tissue complication probabilities (NTCP) for cardiac mortali…

medicine.medical_specialtyRespiratory-Gated Imaging TechniquesHeart Diseasesearly-stage breast cancermedicine.medical_treatmentBreast NeoplasmsMastectomy SegmentalStatistics NonparametricCohort StudiesBreast cancerWhole Breast Irradiationnormal tissue complication probabilitymedicineHumansBreastStage (cooking)Radiation Injuriesrespiratory-gated radiotherapyPneumonitisNeoplasm StagingProbabilitybusiness.industryrespiratory-gated radiotherapy; early-stage breast cancer; breast-conserving therapy; normal tissue complication probabilityPatient SelectionRespirationPulmonary ComplicationRadiotherapy DosageGeneral Medicinemedicine.diseaseLatviaSurgeryRadiation therapyRadiation Pneumonitisbreast-conserving therapyFemaleRadiotherapy AdjuvantRadiotherapy ConformalComplicationbusinessTomography X-Ray ComputedMastectomyMedicina
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